Couples in which one partner carries a chromosomal translocation, inversion, or another type of structural rearrangement.
Structural Rearrangements (PGT-SR)
PGT-SR is an advanced genetic testing technique that allows the identification of structural chromosomal rearrangements in embryos before their transfer into the uterus. This type of analysis is essential in cases where one of the partners carries a chromosomal translocation or inversion, supporting the selection of embryos with optimal reproductive potential.
What is Structural Rearrangements (PGT-SR)?
PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements) is a genetic testing method performed within IVF cycles to detect abnormalities in chromosome structure. These changes may prevent implantation, lead to pregnancy loss, or affect the embryo’s early development.
The procedure involves collecting a small number of cells from the embryo at the blastocyst stage without disrupting its development. The genetic material is analyzed using advanced technologies such as NGS or array-CGH to determine whether the embryo carries inherited structural reorganizations.
By selecting embryos with a balanced chromosomal structure, PGT-SR increases the likelihood of achieving a viable pregnancy and reduces the risk of genetic complications.
Who is Structural Rearrangements (PGT-SR) for?
Patients who have experienced recurrent pregnancy loss caused by genetic abnormalities in the embryos.
Situations in which selecting embryos with a balanced chromosomal structure is desired to increase the chances of a healthy pregnancy.
Treatment steps
Your step-by-step guide to Structural Rearrangements (PGT-SR)
Every treatment is built on a well-defined medical process, carefully structured and tailored to the individual needs of each case. The objective is for the patient to receive clear information, continuous support, and the assurance that every stage is explained in detail—from the initial consultation to the subsequent monitoring period. The entire journey is guided with professionalism, ensuring that medical decisions are made with full understanding.
Although procedures vary depending on each patient’s diagnosis, treatment always begins with a thorough evaluation of the individual situation and the establishment of a personalized strategy. This approach increases the real chances of success and ensures continuity of care throughout the entire journey toward becoming a parent.
Structural Rearrangements (PGT-SR)
During the first meeting, I will review your personal and family medical history to understand the reason we suspect the presence of a chromosomal rearrangement. If needed, I may recommend a blood test for genetic confirmation before beginning treatment.
To perform the test, an IVF cycle is required. The eggs are retrieved, fertilised in the laboratory, and the resulting embryos are cultured until they reach the blastocyst stage — the optimal moment for analysis.
On the appropriate day, the embryologist carefully collects a few cells from the trophectoderm of each embryo and sends them to a genetic laboratory for detailed chromosomal analysis. Embryos remain frozen throughout this process.
Once the results are available, our team will discuss the findings with you and guide you in identifying the embryos with a balanced or normal chromosomal structure for transfer.
A healthy embryo is thawed and transferred into the uterus through a delicate, ultrasound-guided procedure.
Approximately two weeks after the transfer, a blood test is performed to confirm whether implantation has occurred.
Parcursul Pacientului
Parcursul dumneavoastră către a deveni părinte, ghidat cu grijă medicală dedicată
În parcursul către obținerea unei sarcini, fiecare etapă necesită claritate, răbdare și îndrumare medicală adecvată. În practica mea, acord o atenție deosebită înțelegerii situației dumneavoastră individuale și ofer recomandări adaptate nevoilor specifice ale fiecărui pacient. Obiectivul meu este să vă sprijin cu profesionalism și empatie, astfel încât să aveți încredere în fiecare pas al procesului.
Contactați-mă
Puteți lua legătura direct cu mine pentru clarificări, informații suplimentare sau programarea unei consultații.
Programați o consultație
Stabiliți o întâlnire medicală pentru evaluarea situației dumneavoastră și discutarea opțiunilor de tratament.
Definirea planului dumneavoastră de tratament
Stabilirea unui plan terapeutic personalizat, adaptat diagnosticului și nevoilor dumneavoastră medicale.
Fiecare parcurs medical este diferit
Fiecare pacient are un traseu unic în evaluarea și tratarea infertilității. Vă sprijin cu atenție și profesionalism în fiecare etapă.
F.A.Q.
Structural Rearrangements (PGT-SR) F.A.Q.
Starting a treatment or medical procedure often raises questions regarding safety, effectiveness, and its impact on fertility. This section provides general explanations to help patients better understand the working steps, what the procedure involves, and what results to expect. The information is presented in an accessible manner to facilitate a clearer understanding of the medical process.
If additional questions arise or if the individual situation requires specific clarifications, a direct discussion with the physician can offer personalized guidance and recommendations tailored to each case. Proper guidance supports informed decision-making and ensures that treatment proceeds safely.
A structural rearrangement is a change in the architecture of chromosomes — such as a translocation or an inversion — which may lead to the development of embryos with unbalanced genetic material. If you carry such a variant, it does not necessarily affect your own health, but it can influence fertility.
I recommend this test if you or your partner are known carriers of a chromosomal rearrangement, or if there is a history of recurrent miscarriages, embryos with anomalies, or repeated implantation failure. Your specific medical situation helps determine whether PGT-SR is needed.
No, they are different tests. PGT-A identifies numerical chromosomal abnormalities (extra or missing chromosomes). PGT-SR is a more specific test focused on detecting structural rearrangements that disrupt the proper organisation of the genetic material.
In most cases, no. Individuals who carry a balanced translocation are typically healthy and lead normal lives. The challenge arises in fertility, because the translocation can lead to embryos with unbalanced chromosomal structures.
Biopsies are performed exclusively by highly trained embryologists, and the cells are taken from the trophectoderm — the part of the embryo that later forms the placenta, not the baby. Embryos are frozen immediately afterwards for safety. The risk of damage is extremely low.
PGT-SR significantly reduces the risk of transferring embryos with chromosomal abnormalities related to the rearrangement, but no test can completely eliminate all possible genetic risks. However, careful selection greatly increases the chances of a healthy pregnancy.
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Structural Rearrangements (PGT-SR)
If you have questions related to structural rearrangements (PGT-SR) or would like recommendations on evaluating and monitoring your newborn during the first days of life, you may request an individual consultation at any time. A thorough assessment helps determine the most suitable monitoring and support plan for your child.
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