Couples whose infertility is related to altered sperm parameters, including low count, reduced motility, or abnormal morphology.
Intracytoplasmic Sperm Injection (ICSI)
ICSI is an advanced fertilisation technique used in assisted reproduction, designed especially for situations in which sperm cells encounter difficulties fertilising the oocyte naturally. Through this method, a single sperm cell is injected directly into the oocyte using highly precise microscopic instruments, significantly increasing the chances of obtaining viable embryos in an IVF cycle.
What is Intracytoplasmic Sperm Injection (ICSI)?
ICSI is a laboratory procedure in which fertilisation is facilitated by directly injecting one sperm cell into the oocyte. The technique is performed using specialised microscopic equipment and overcomes specific obstacles to natural fertilisation, making it one of the most effective methods in cases involving pronounced male-factor infertility.
The procedure is recommended when there are significant alterations in sperm parameters—such as low sperm count, reduced motility, or morphological abnormalities—or when conventional fertilisation has been unsuccessful in previous cycles. ICSI provides enhanced control over every step of the fertilisation process.
In certain situations, ICSI forms part of a broader therapeutic protocol, which may also include embryo genetic testing (PGT-A, PGT-SR, or PGT-M), oocyte or embryo vitrification, or additional techniques aimed at optimising the overall success rate of treatment.
Who is Intracytoplasmic Sperm Injection (ICSI) for?
Situations in which conventional fertilisation has failed in previous IVF cycles or when a limited sperm response is anticipated.
Patients who require a highly precise fertilisation technique, particularly in the context of genetic testing or more complex therapeutic protocols.
Treatment steps
Your step-by-step guide to Intracytoplasmic Sperm Injection (ICSI)
Every treatment is built on a well-defined medical process, carefully structured and tailored to the individual needs of each case. The objective is for the patient to receive clear information, continuous support, and the assurance that every stage is explained in detail—from the initial consultation to the subsequent monitoring period. The entire journey is guided with professionalism, ensuring that medical decisions are made with full understanding.
Although procedures vary depending on each patient’s diagnosis, treatment always begins with a thorough evaluation of the individual situation and the establishment of a personalized strategy. This approach increases the real chances of success and ensures continuity of care throughout the entire journey toward becoming a parent.
Intracytoplasmic Sperm Injection (ICSI)
During the first consultation, we will discuss your fertility history and the results of all tests performed so far. This helps us determine whether ICSI is the right option for your situation and what real benefits it may offer.
Similar to a standard IVF cycle, you will follow a hormonal stimulation protocol to encourage egg production. Throughout the process, we closely monitor your progress using ultrasound and blood tests to track follicular development and adjust treatment for an optimal response.
Eggs are collected under light sedation in a short, well-tolerated procedure. At the same time, a sperm sample is collected and prepared. If necessary, sperm can be retrieved surgically. Both samples are prepared immediately for the laboratory stage.
In the laboratory, each mature egg is injected with a single sperm cell using advanced micromanipulation techniques. This approach ensures fertilization even when sperm quality is severely impaired. Each step is carefully monitored to confirm that embryos are developing normally.
We select the best-quality embryo and transfer it into the uterus using a gentle, quick, and painless procedure guided by ultrasound. Additional embryos may be frozen for future use.
Approximately two weeks after the transfer, a blood test is performed to confirm whether implantation has occurred and pregnancy has been achieved.
Parcursul Pacientului
Parcursul dumneavoastră către a deveni părinte, ghidat cu grijă medicală dedicată
În parcursul către obținerea unei sarcini, fiecare etapă necesită claritate, răbdare și îndrumare medicală adecvată. În practica mea, acord o atenție deosebită înțelegerii situației dumneavoastră individuale și ofer recomandări adaptate nevoilor specifice ale fiecărui pacient. Obiectivul meu este să vă sprijin cu profesionalism și empatie, astfel încât să aveți încredere în fiecare pas al procesului.
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Stabiliți o întâlnire medicală pentru evaluarea situației dumneavoastră și discutarea opțiunilor de tratament.
Definirea planului dumneavoastră de tratament
Stabilirea unui plan terapeutic personalizat, adaptat diagnosticului și nevoilor dumneavoastră medicale.
Fiecare parcurs medical este diferit
Fiecare pacient are un traseu unic în evaluarea și tratarea infertilității. Vă sprijin cu atenție și profesionalism în fiecare etapă.
F.A.Q.
Intracytoplasmic Sperm Injection (ICSI) F.A.Q.
Starting a treatment or medical procedure often raises questions regarding safety, effectiveness, and its impact on fertility. This section provides general explanations to help patients better understand the working steps, what the procedure involves, and what results to expect. The information is presented in an accessible manner to facilitate a clearer understanding of the medical process.
If additional questions arise or if the individual situation requires specific clarifications, a direct discussion with the physician can offer personalized guidance and recommendations tailored to each case. Proper guidance supports informed decision-making and ensures that treatment proceeds safely.
Both procedures involve fertilizing the eggs in the laboratory. In ICSI, a single sperm cell is injected directly into an egg, while in IVF sperm are left to fertilize the egg naturally in the laboratory environment.
ICSI may increase fertilization rates in cases of male-factor infertility, but the final success depends on your age, egg quality, and embryo development. We will determine together whether this method offers a real benefit for your situation.
Current evidence shows that when performed correctly and all safety protocols are followed, ICSI does not increase health risks for the child. We closely monitor each stage to ensure optimal conditions.
No. ICSI is specifically indicated for severe male-factor infertility or after repeated IVF fertilization failures. If it is not necessary in your case, we will not recommend it.
Yes. ICSI is highly effective even when using frozen sperm or surgically retrieved sperm.
Each mature egg available on the day of retrieval can be injected with a single sperm cell. The final number depends on how many mature eggs are collected.
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Intracytoplasmic Sperm Injection (ICSI)
If you have questions related to intracytoplasmic sperm injection (ICSI) or would like recommendations on evaluating and monitoring your newborn during the first days of life, you may request an individual consultation at any time. A thorough assessment helps determine the most suitable monitoring and support plan for your child.
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Published 28 Nov, 2025
