Thrombophilia is a condition in which the blood has an increased tendency to clot, forming blockages inside the vessels. While coagulation is essential in stopping bleeding caused by injuries, clot formation in the absence of trauma poses a serious health risk. Detached clots can travel through the bloodstream and obstruct vital organs such as the heart, lungs, or brain. Individuals with thrombophilia have a higher risk of deep vein thrombosis, pulmonary embolism, heart attack, or stroke.

The condition affects approximately one in five people, but many cases remain undiagnosed because thrombophilia is often asymptomatic until a clot occurs.

Thrombophilia can be inherited, due to genetic mutations passed from parents, or acquired, appearing in the context of medical conditions such as surgeries, trauma, cancer, or autoimmune disorders. The most common inherited forms include Factor V Leiden and prothrombin (Factor II) mutations.

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Thrombophilia and Miscarriage

Infertility refers both to difficulty conceiving and to the inability to maintain a pregnancy. Around 40–50% of miscarriages are associated with thrombophilia, making it a significant contributing factor.

Pregnant women with thrombophilia face increased risks of:

• recurrent miscarriage
• deep vein thrombosis
• severe preeclampsia
• placental abruption
• intrauterine fetal death

Clots that block placental blood flow deprive the embryo or fetus of oxygen and nutrients, leading to pregnancy loss.

With Proper Treatment, Pregnancy Is Possible

Diagnosis is made through genetic and hematological testing, especially in cases of recurrent miscarriages without explanation. Testing may also be recommended in women with PCOS, diabetes, or a family history of thrombosis.

Thrombophilia does not prevent a woman from becoming a mother. Successful pregnancy is achievable through coordinated care between a fertility specialist and a hematologist experienced in managing thrombophilia during pregnancy. Anticoagulant treatment and close monitoring significantly improve outcomes and support the development of a healthy baby.

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Thrombophilia

If you have questions related to thrombophilia or would like recommendations on evaluating and monitoring your newborn during the first days of life, you may request an individual consultation at any time. A thorough assessment helps determine the most suitable monitoring and support plan for your child.

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