{"id":6098,"date":"2026-04-18T16:07:35","date_gmt":"2026-04-18T14:07:35","guid":{"rendered":"https:\/\/vythoulkas.ro\/screening-genetic-preimplantational-cand-recomand\/"},"modified":"2026-03-24T12:12:58","modified_gmt":"2026-03-24T10:12:58","slug":"preimplantation-genetic-testing-when-i-recommend","status":"publish","type":"post","link":"https:\/\/vythoulkas.ro\/en\/preimplantation-genetic-testing-when-i-recommend\/","title":{"rendered":"When I Recommend PGT and What Couples Should Know Before This Stage"},"content":{"rendered":"\n

When I discuss the options available within a fertility journey, I often explain that In Vitro Fertilization (IVF): the patient experience<\/strong> does not refer only to the procedure itself, but also to the careful choice of stages that make sense for that particular case.<\/p>\n\n\n\n

In this context, the discussion about preimplantation genetic testing may also arise.<\/p>\n\n\n\n

In my practice, I do not automatically recommend this stage to all couples who reach IVF.<\/p>\n\n\n\n

I recommend it only when there is a real medical justification, when the information obtained may be useful in decision-making and when the couple clearly understands both the benefits and the limitations of the testing.<\/p>\n\n\n\n

PGT is part of modern reproductive medicine, but it should be viewed neither as a guarantee nor as a mandatory stage in every protocol.<\/p>\n\n\n\n

In What Situations I Consider PGT<\/h2>\n\n\n\n

There are situations in which this stage may be easier to justify, for example when I am dealing with an increased risk of chromosomal abnormalities, a history of recurrent pregnancy loss, repeated failures in certain contexts or when there are genetic suspicions or confirmed findings that require a closer evaluation before transfer.<\/p>\n\n\n\n

In such cases, I do not look only at the test itself, but at the entire clinical picture.<\/p>\n\n\n\n

This is why I integrate this discussion together with the explanations on the page about PGT-A aneuploidy screening<\/strong> and, when needed, with a well-conducted stage of genetic counseling before the decision is made.<\/p>\n\n\n\n

From my clinical experience, one of the most important clarifications is that preimplantation genetic testing is not the same thing in every situation.<\/p>\n\n\n\n

There are forms of PGT that focus on aneuploidies, while others are aimed at monogenic diseases or structural chromosomal rearrangements.<\/p>\n\n\n\n

That is exactly why the recommendation is not made generically, but according to the medical question we are trying to answer.<\/p>\n\n\n\n

Sometimes, the discussion appears in a protocol using the patient\u2019s own oocytes, while in other cases it may arise in a more complex context, including when I evaluate alternatives such as egg donation<\/strong>, if ovarian age or ovarian reserve realistically changes the strategy.<\/p>\n\n\n\n

What This Testing May Show and What It Cannot Promise<\/h2>\n\n\n\n

When I explain what preimplantation genetic testing means, I insist on one essential point: this testing may provide useful information about certain genetic or chromosomal characteristics of embryos, but it cannot promise a certain pregnancy and it cannot guarantee the birth of a healthy child in an absolute sense.<\/p>\n\n\n\n

This is one of the most important nuances.<\/p>\n\n\n\n

Some professional guidelines clearly emphasize that PGT is not uniformly perfect and that, after pregnancy is achieved, prenatal screening and, when indicated, prenatal diagnosis remain important.<\/p>\n\n\n\n

In addition, I often explain that preimplantation genetic testing may reduce the number of embryos considered eligible for transfer and, in some cycles, may lead to a situation in which no embryos remain available for transfer after the results are received.<\/p>\n\n\n\n

This reality must be stated clearly before beginning that stage.<\/p>\n\n\n\n

In certain cases, the selection of a euploid embryo may be useful in choosing the transfer, but this does not automatically mean a demonstrated increase in the final chance of having a child for all categories of patients.<\/p>\n\n\n\n

That is why I avoid presenting preimplantation genetic testing as a universal solution and prefer to discuss it as a tool that must be used with discernment.<\/p>\n\n\n\n

What I Clarify Before Recommending This Stage<\/h2>\n\n\n\n

Before I recommend preimplantation genetic testing, I look at several things.<\/p>\n\n\n\n

First, I make sure that the medical indication is coherent.<\/p>\n\n\n\n

Second, I explain the practical steps: obtaining embryos \u05d1\u05de\u05e1\u05d2\u05e8\u05ea an in vitro fertilization protocol, embryo biopsy, genetic analysis and, in most cases, a later transfer after the results are received.<\/p>\n\n\n\n

At the same time, I consider it important to discuss the additional time involved, the costs, the emotional impact and the possibility that the result may not always decisively change the plan.<\/p>\n\n\n\n

I also do not ignore the patient\u2019s overall biological context.<\/p>\n\n\n\n

In my practice, before such stages, I also look for factors that may influence the safety or organization of treatment, including infections or local imbalances, which is why I sometimes integrate evaluations such as those discussed in the article about bacterial vaginosis before fertility procedures<\/strong>.<\/p>\n\n\n\n

Preimplantation genetic testing should not be viewed in isolation, but as part of a broader, well-structured plan.<\/p>\n\n\n\n

I often tell couples a few simple ideas that are worth keeping in mind:<\/p>\n\n\n\n