{"id":3394,"date":"2025-11-01T16:30:59","date_gmt":"2025-11-01T14:30:59","guid":{"rendered":"https:\/\/vythoulkas.ro\/testul-kir-hla-c-cand-este-indicat-si-ce-arata-rezultatele\/"},"modified":"2025-12-01T17:34:46","modified_gmt":"2025-12-01T15:34:46","slug":"the-kir-hla-c-test-when-it-is-indicated-and-what-the-results-reveal","status":"publish","type":"post","link":"https:\/\/vythoulkas.ro\/en\/the-kir-hla-c-test-when-it-is-indicated-and-what-the-results-reveal\/","title":{"rendered":"The KIR\/HLA-C Test \u2013 When It Is Indicated and What the Results Reveal"},"content":{"rendered":"\n<p><a href=\"https:\/\/vythoulkas.ro\/wp-content\/uploads\/2017\/06\/11ac756b13861946a4129cc45fbcefd8.jpg\"><\/a>The KIR\/HLA-C test may be recommended by a fertility specialist when a patient experiences repeated embryo implantation failures or recurrent miscarriages.<\/p>\n\n\n\n<p>Below is a clearer explanation of what this test involves and what the results can indicate.<\/p>\n\n\n\n<section class=\"quote-component full bg-tutu-400 py-[40px] overflow-hidden\">\n    <div class=\"section-container mx-auto px-4\">\n        <div class=\"lg:grid flex flex-col lg:grid-rows-4 grid-cols-6 lg:gap-x-[12px] items-start\">\n\n            <div class=\"col-start-1 col-end-7 lg:col-end-5 row-start-1 row-end-3 lg:row-end-3 flex flex-col lg:block\">\n                                    <h2 class=\"inline font-light m-0 align-bottom\">\n                        \u201cYou deserve to be heard, seen, treated with respect, and supported throughout your life.\u201d                    <\/h2>\n                \n                            <\/div>\n\n            <div class=\"grid self-stretch grid-cols-6 grid-rows-4 h-full lg:contents\">\n                                    <div class=\"lg:max-w-full max-w-[410px] -mb-[20px] lg:m-0 col-start-4 lg:col-start-5 col-end-7 row-start-1 row-end-3 lg:row-start-1 lg:row-end-4 self-stretch overflow-hidden\">\n                        <img decoding=\"async\" src=\"https:\/\/vythoulkas.ro\/wp-content\/uploads\/2025\/10\/Doctor-Patient-Care.jpg\" alt=\"Ilustra\u021bie cu Dr. Andreas Vythoulkas oferind sprijin \u0219i \u00eengrijire personalizat\u0103 unei paciente \u00een cadrul tratamentelor FIV.\" class=\"w-full h-full object-cover\">\n                    <\/div>\n                \n                                    <div class=\"max-h-[min(50vw,300px)] lg:max-h-[462px] col-start-1 col-end-6 row-start-3 row-end-5 lg:col-start-2 lg:col-end-5 lg:row-start-3 lg:row-end-5 self-stretch overflow-hidden\">\n                        <img decoding=\"async\" src=\"https:\/\/vythoulkas.ro\/wp-content\/uploads\/2025\/10\/Expecting-Mother.jpg\" alt=\"Ilustra\u021bie cu o femeie \u00eens\u0103rcinat\u0103 reprezent\u00e2nd succesul tratamentelor de fertilitate oferite de Dr. Andreas Vythoulkas.\" class=\"w-full h-full object-cover\">\n                    <\/div>\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Why the KIR\/HLA-C Test Is Recommended<\/strong><\/h2>\n\n\n\n<p>Uterine adaptation to the fetus is a complex immunological process that involves the interaction between KIR receptors (Killer Immunoglobulin Receptors) expressed by maternal immune cells in the uterus (NK cells) and their ligands, known as HLA-C (Human Leukocyte Antigen-C).<\/p>\n\n\n\n<p>The risk that the maternal immune system might \u201creject\u201d the embryo can be evaluated through the genetically determined immune compatibility test KIR\/HLA-C.<\/p>\n\n\n\n<p>This blood test helps the physician determine the most appropriate therapeutic protocol for couples facing infertility.<\/p>\n\n\n\n<p>The KIR\/HLA-C test may be indicated in the following situations:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Repeated IVF failures (implantation failure)<\/li>\n\n\n\n<li>Recurrent pregnancy loss (repeated miscarriages)<\/li>\n\n\n\n<li>History of preeclampsia or preterm birth<\/li>\n\n\n\n<li>Before IVF with donated oocytes (to assess compatibility between donor and recipient)<\/li>\n\n\n\n<li>To determine the optimal number of embryos for transfer<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>How the KIR\/HLA-C Test Is Performed<\/strong><\/h2>\n\n\n\n<p>The test involves collecting a blood sample from both partners and, when donor eggs or sperm are used, from the donor as well.<\/p>\n\n\n\n<p>The results, interpreted by a genetic specialist, can help identify an immunologic cause of infertility and guide the most suitable treatment plan.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>KIR\/HLA-C Incompatibility: What Can Be Done?<\/strong><\/h2>\n\n\n\n<p>If the results show KIR\/HLA-C incompatibility, the fertility specialist can tailor the therapeutic approach accordingly.<\/p>\n\n\n\n<p>Options may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>immunomodulatory treatment for the woman (to increase immunological tolerance)<\/li>\n\n\n\n<li>transferring a single embryo (to avoid potential dual exposure to incompatible HLA-C)<\/li>\n<\/ul>\n\n\n\n<section class=\"talk-to-expert-component my-[80px] lg:my-[120px]\">\n    <div class=\"section-container mx-auto bg-baby-blue-100 max-w-[1116px]\">\n        <div class=\"grid grid-cols-1 lg:grid-cols-2 items-stretch gap-[40px]\">\n\n            <!-- Left Column: Text Content -->\n            <div class=\"flex flex-col justify-start items-start gap-[40px] px-[18px] lg:pl-[40px] pt-[40px] lg:pb-[20px] lg:pr-0\">\n                                    <span class=\"font-[450] m-0 body-md\">Contact me<\/span>\n                \n                                    <h4 class=\"font-normal m-0\">\n                        Talk with me about                                                    <br><strong class=\"font-bold bg-baby-blue-300\" >The KIR\/HLA-C Test<\/strong>\n                                            <\/h4>\n                \n                                    <div class=\"m-0 body-md wysiwyg-content\">\n                        If you have questions related to the KIR\/HLA-C test or would like recommendations on evaluating and monitoring your newborn during the first days of life, you may request an individual consultation at any time. A thorough assessment helps determine the most suitable monitoring and support plan for your child.                    <\/div>\n                \n                                    <div class=\"align-self-end\">\n                        \n<a href=\"https:\/\/vythoulkas.ro\/en\/contact\/\"\n   target=\"_self\"\n   class=\"group inline-flex items-center gap-2 h-14 py-2 rounded-full border-[1px] transition-colors duration-300 hover:no-underline border-baby-blue-800 hover:border-baby-blue-500 text-baby-blue-800 hover:text-baby-blue-800 pl-6 pr-2\">\n\n    <span class=\"font-[400] text-base whitespace-nowrap\">Talk with me now<\/span>\n            <span class=\"flex items-center justify-center w-10 h-10 duration-300 transition-transform rounded-full bg-baby-blue-800 text-baby-blue-100 -rotate-45 group-hover:rotate-0\">\n             <svg class=\"w-6 h-6 text-baby-blue-100\" fill=\"none\" stroke=\"currentColor\" viewBox=\"0 0 24 24\"\n                  xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n                  <path stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\"2\" d=\"M14 5l7 7m0 0l-7 7m7-7H3\"><\/path>\n             <\/svg>\n        <\/span>\n    <\/a>\n                    <\/div>\n                            <\/div>\n\n            <!-- Right Column: Image -->\n            <div class=\"items-stretch flex\">\n                <div class=\"relative w-full h-full overflow-hidden\">\n                                            <img decoding=\"async\" class=\"lg:inset-0 lg:absolute w-full h-full max-h-full block object-cover\" src=\"https:\/\/vythoulkas.ro\/wp-content\/uploads\/2025\/10\/Program-National-FIV-2025.-Etape-Eligibilitate-Costuri.jpg\" alt=\"Program Na\u021bional FIV 2025 | Etape, Eligibilitate &amp; Costuri\">\n                                    <\/div>\n            <\/div>\n\n        <\/div>\n    <\/div>\n<\/section>\n<style>\n    @media screen and (max-width: 992px) {\n        .talk-to-expert-component {\n            padding-left: 0;\n            padding-right: 0;\n        }\n        \/*.expert-subtitle {\n            color: var(--text-body, #262B2F);\n            leading-trim: both;\n            text-edge: cap;\n            font-kerning: none;\n\n            !* Body\/Body Medium Mobile *!\n            font-family: var(--type-font-family-secondary);\n            font-size: var(--font-size-body-sm, 16px);\n            font-style: normal;\n            font-weight: 450;\n            line-height: var(--line-height-body-sm, 24px); !* 150% *!\n        }*\/\n    }\n<\/style>\n","protected":false},"excerpt":{"rendered":"<p>Learn when the KIR\/HLA-C test is recommended, how it works, and what the results mean for couples with implantation failure or recurrent miscarriage.<\/p>\n","protected":false},"author":3,"featured_media":2392,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[7],"tags":[],"post_author":[],"class_list":["post-3394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles"],"acf":[],"_links":{"self":[{"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/posts\/3394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/comments?post=3394"}],"version-history":[{"count":2,"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/posts\/3394\/revisions"}],"predecessor-version":[{"id":3464,"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/posts\/3394\/revisions\/3464"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/media\/2392"}],"wp:attachment":[{"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/media?parent=3394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/categories?post=3394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/tags?post=3394"},{"taxonomy":"post_author","embeddable":true,"href":"https:\/\/vythoulkas.ro\/en\/wp-json\/wp\/v2\/post_author?post=3394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}